Premique - dosage, use, side effects, indications

Premique is a type of hormone replacement therapy (HRT) that contains two active ingredients, Estradiol and Medroxyprogesterone acetate. These are naturally occurring female sex hormones, Estradiol being an estrogen and Medroxyprogesterone an artificial form of progesterone.

The action of Premique is primarily to restore the hormonal balance in menopausal women. During menopause, the amount of estrogen produced by the ovaries decreases, leading to symptoms such as hot flashes, night sweats, mood swings, and vaginal dryness or itching. The Estradiol in Premique supplements the declining levels of estrogen and helps to alleviate these symptoms.

The Medroxyprogesterone in Premique plays a crucial role in preventing overgrowth of the womb lining (endometrial hyperplasia) that can happen due to an increase in estrogen levels. This is particularly important as endometrial hyperplasia can lead to endometrial cancer. Therefore, Medroxyprogesterone acts as a protective agent for the uterus.

In conclusion, the action of Premique is dual: it both alleviates menopausal symptoms and prevents potential risks associated with estrogen-only therapy.

Premique is indicated for the treatment of symptoms of estrogen deficiency in postmenopausal women more than one year after menopause. The primary indication is for the relief of post-menopausal symptoms, including hot flashes, night sweats, vaginal dryness, burning, and irritation.

In addition, it is used for the prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis.

Premique should not be prescribed to women who have not had a hysterectomy, unless they are also prescribed a progestogen. This is because estrogen on its own increases the risk of cancer of the lining of the womb (endometrial cancer). Adding a progestogen for at least 12 days of each month can prevent this increased risk.

The treatment should only be continued as long as the benefit in the reduction of menopausal symptoms outweighs the risks associated with hormone replacement therapy.

Contrary to many medications, Premique isn't suitable for everyone. There are certain circumstances and medical conditions that may prevent you from safely using this drug. These are known as contraindications.

First and foremost, women who are pregnant or suspect they may be pregnant should not take Premique, as it can cause harm to the unborn baby. Similarly, it's not recommended for breastfeeding mothers, as it can pass into the breast milk and potentially harm a nursing infant.

Individuals with a history of or current breast cancer or estrogen-dependent cancer shouldn't use Premique. This extends to those with unexplained vaginal bleeding and those who have or have had blood clots in the veins, such as deep vein thrombosis or pulmonary embolism.

Patients with known, past or suspected breast cancer should not use Premique. Nor should patients with known or suspected estrogen-dependent malignant tumours for example endometrial cancer.

The contraindications for Premique also include those with liver disease or liver dysfunction, as Premique can further impair liver function. It's also not recommended in people with a history of heart disease or stroke, due to the increased risk of developing these conditions when taking Premique.

Lastly, Premique is contraindicated in individuals who are allergic to any of the ingredients in the medication. This includes both the active and inactive ingredients. Therefore, it's crucial to discuss with your healthcare provider about any allergies you may have before beginning a course of Premique.

Premique, like any other medication, may cause certain side effects. However, not everyone who takes the drug will experience these. Some of the common side effects of Premique may include bloating, breast tenderness, headaches, mood changes, and stomach cramps.

In addition to these common side effects, Premique may also cause some serious side effects. These may include signs of a blood clot (such as sudden dizziness, severe headaches, and changes in vision), symptoms of a heart attack (like chest/jaw/left arm pain), and changes in vaginal bleeding (such as spotting, breakthrough bleeding, prolonged or heavy bleeding, and missed periods).

• If you notice any of these symptoms, you should contact your doctor immediately.
• Moreover, it is also necessary to seek immediate medical attention if you experience sudden or severe abdominal/pelvic pain, or if you feel lightheaded or faint.

Keep in mind that your doctor has prescribed this medication because they have judged that the benefits outweigh the risk of side effects. Many people using this medication do not have serious side effects.

Please remember that this is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The dosage of Premique depends on the individual treatment plan and the specific needs of the patient. It is important to take Premique as directed by your healthcare provider. The usual recommended dosage for menopausal symptoms is one tablet taken orally once a day. The tablet should be swallowed whole with a glass of water and can be taken with or without food.

If you miss a dose of Premique, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at the same time or extra doses.

Overdose of Premique can lead to nausea, vomiting, and vaginal bleeding. If you suspect an overdose or experience any severe or unusual side effects, contact your healthcare provider immediately or seek medical attention.

Keep in mind that the dosage may vary depending on other health conditions you have or other medications you are taking. Always follow the dosage instructions provided by your healthcare provider and do not alter the dosage without consulting with them first.

Premique is used for the treatment of symptoms associated with menopause. It is a form of Hormone Replacement Therapy (HRT) that combines two hormones, estrogen and progestogen. Premique is specifically designed to help women who have had their womb removed (a hysterectomy). It can also be used by women who have not had a hysterectomy but who have stopped having periods and are unable to take a different type of HRT for whatever reason.

Premique is primarily used to relieve the symptoms of menopause. This includes hot flashes, night sweats, mood swings, sleep problems, and vaginal dryness or discomfort. Women may also use Premique to prevent osteoporosis (a condition that weakens the bones) if they have a high risk of future fractures and other treatments are not suitable.

The dosage and duration of Premique use are determined by the doctor, based on the individual patient's condition and response to treatment. It is typically taken orally once a day. It's important to follow your doctor's directions carefully and to continue taking Premique even if you feel well. Do not take more or less of it or take it more often than prescribed by your doctor.

Regular check-ups with your doctor are essential while using Premique. These visits allow the doctor to monitor your progress and to make sure that Premique is not causing unwanted effects. If you have any concerns or experience any side effects, it's important to consult your doctor immediately.

When using Premique, there are several precautions that should be considered to ensure safe and effective use. Some precautions to keep in mind include:

• Before starting treatment, inform your doctor about your medical history, especially if you have had a stroke, heart disease, liver disease, kidney disease, high blood cholesterol or triglyceride levels, high or low blood pressure, breast lumps, or diabetes.
• Inform your doctor if you are pregnant or plan to become pregnant. Premique should not be used during pregnancy as it may harm an unborn baby.
• Smoking while taking Premique may increase your risk of serious side effects such as heart disease, stroke, or blood clots, especially in women over 35. Consult your doctor for more details.
• Regular physical exams and mammograms are recommended while using Premique to check for conditions that may be caused by the medication.
• This medication should not be used in children. Consult your doctor for more details.
• Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.

Premique is a hormone replacement therapy (HRT) used to treat symptoms of menopause. However, its efficacy can be affected by certain drug interactions. It is important to be aware of these interactions before starting the therapy.

Some of the potential interactions that may occur with Premique include:

• Drugs that can increase the breakdown of Premique in the body, leading to decreased effectiveness. These include certain anticonvulsants (such as phenobarbital, phenytoin, carbamazepine), antifungals (such as griseofulvin) and anti-infectives (such as rifampicin, rifabutin).
• Drugs that can decrease the breakdown of Premique in the body, leading to increased effects and side effects. These include certain antifungals (such as ketoconazole, itraconazole), protease inhibitors used in the treatment of HIV (such as ritonavir, nelfinavir) and certain macrolide antibiotics (such as erythromycin, clarithromycin).
• Certain drugs used to treat chronic hepatitis C (such as ombitasvir/paritaprevir/ritonavir) may increase the risk of liver problems.

Furthermore, Premique may interfere with certain lab tests, potentially causing false test results. Ensure laboratory personnel and all your healthcare providers know you use this drug. It is essential to tell your doctor or pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with Premique.

The price of Premique can greatly vary depending on the location and the pharmacy where it is purchased. It is important to note that the cost is often influenced by the quantity purchased as well as the dosage. In general, the price range of Premique can be anywhere from $30 to $50 for a pack of 28 tablets.

Healthcare providers and pharmacists often recommend comparing prices from different pharmacies to get the best deal. Some pharmacies may offer discounts or coupons which can significantly reduce the cost. It's also worth checking if your health insurance covers the cost of this medication.

Online pharmacies can sometimes offer more competitive prices. However, caution must be exercised when purchasing medication online to ensure the pharmacy is reputable and the medication is genuine. Always check the credentials of the online pharmacy before making a purchase.

In addition, it's necessary to consider the cost of regular doctor’s visits for check-ups and prescription renewals when calculating the overall cost of taking Premique. Financial assistance or patient assistance programs may be available for those who cannot afford their medications. It's worthwhile speaking to your health provider or pharmacist about these options.

There are several substitutes available for Premique on the market. However, it's important to note that these substitutes might not have the same composition or strength as Premique. They can only be substituted if recommended by a healthcare professional.

• Elleste Duet
• Kliovance
• Evorel Conti
• Evorel Sequi

While these are some of the substitutes for Premique, it's crucial to consult your healthcare professional before switching to a different medication. The substitutes listed above may have different strengths and side effects, and may not be suitable for everyone.