Evorel Conti - dosage, contraindications, indications, use

Evorel Conti is a Hormone Replacement Therapy (HRT) that contains two types of female hormones: an estrogen (estradiol) and a progestogen (norethisterone). These hormones are naturally produced by the female body and their levels decline during menopause. The action of Evorel Conti revolves around replenishing these hormone levels, which helps to relieve the symptoms of menopause.

Evorel Conti patches are applied to the skin, from where the hormones are directly absorbed into the bloodstream. The estradiol in Evorel Conti is identical to the naturally occurring estradiol and it works to alleviate symptoms like hot flushes, night sweats, mood swings, and vaginal dryness or itching.

The norethisterone in Evorel Conti is a synthetic form of progesterone. It is included in the formulation to protect the lining of the uterus from overgrowth and cancer, which can occur due to the effects of estrogen alone. The combination of these two hormones in Evorel Conti helps to restore hormonal balance and alleviate menopause symptoms.

Evorel Conti is primarily prescribed for the management of signs and symptoms associated with menopause. This includes hot flushes, night sweats, sleep disturbances, mood swings, and vaginal dryness or discomfort. It is intended for use in women who still have their womb, as the product contains estradiol, a form of estrogen, and norethisterone, a type of progestogen. The combination of these two hormones can help to replace the falling hormone levels in the body and help to control menopausal symptoms.

Furthermore, Evorel Conti may also be indicated for the prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other osteoporosis treatments. Osteoporosis is a condition that weakens bones, making them fragile and more likely to break. As estrogen levels drop during menopause, the risk of developing osteoporosis increases. The estradiol in Evorel Conti can help maintain bone density and reduce the risk of fractures.

It's important to note that Evorel Conti should only be used if the symptoms seriously affect quality of life. The treatment should be periodically reviewed with a healthcare professional, preferably at least once a year, to ensure it's still necessary and beneficial.

Evorel Conti, a hormone replacement therapy (HRT), is not suitable for everyone and should not be used in certain circumstances. It’s important to know these contraindications to ensure the safe use of this medication.

The use of Evorel Conti is contraindicated in the following conditions:

• Known, past or suspected breast cancer
• Known or suspected estrogen-dependent malignant tumors (e.g., endometrial cancer)
• Undiagnosed genital bleeding
• Untreated endometrial hyperplasia
• Previous or current venous thromboembolism (deep venous thrombosis, pulmonary embolism)
• Known thrombophilic disorders
• Active or recent arterial thromboembolic disease (e.g., angina, myocardial infarction)
• Acute liver disease, or a history of liver disease as long as liver function tests have failed to return to normal
• Known hypersensitivity to the active substances or to any of the excipients
• Porphyria

Additionally, Evorel Conti should not be used by pregnant or breastfeeding women as it may harm the baby. It is important to inform your healthcare provider about any medical conditions or allergies you have before starting this medication.

Like any other medication, Evorel Conti also has some potential side effects. It's crucial to know that not everyone experiences these side effects, and they are often manageable. The side effects can range from mild to severe, and they can become less noticeable over time as your body adjusts to the medication. However, if they persist or become bothering, it's important to seek medical attention.

Some of the common side effects of Evorel Conti include headaches, breast tenderness or pain, irregular periods or spotting, nausea, and skin irritation at the site of the patch. These are usually mild and should go away after a few days to a week.

Some serious side effects may occur, although they are rare. These include signs of blood clots such as sudden severe headache, pain in the chest, breathlessness, abnormal vision, and swelling or pain in the leg. If you notice any of these symptoms, it's important to seek medical help immediately.

Other less common but serious side effects include yellowing of the skin or eyes, severe abdominal pain, and unusual tiredness or weakness. These may be signs of liver problems and require immediate medical attention.

It's important to remember that this is not a complete list of side effects, and others may occur. Always consult your doctor or pharmacist for medical advice about side effects. If you suspect you have experienced a side effect, you can report it using the Yellow Card Scheme.

The dosage of Evorel Conti is typically determined by the patient's specific medical condition and their response to treatment. It's crucial to follow the exact dosage prescribed by your healthcare provider to ensure the medication's effectiveness.

Evorel Conti is a transdermal patch that needs to be applied to the skin. The standard dose is one patch applied twice weekly. The patches are usually changed every 3 to 4 days, or as directed by your healthcare provider. The patch should be applied to a clean, dry, and hairless area of the skin below the waist. It should not be applied to the breasts or on irritated skin.

It's essential to use the patches consistently to maintain a steady level of the medication in your body. Therefore, it may be helpful to apply the patches on the same days each week. If a dose is missed, it should be applied as soon as possible. However, if it's near the time for the next dose, the missed dose should be skipped.

It's important to note that the dosage may need to be adjusted over time, particularly if you experience any side effects or if your symptoms persist or worsen. Regular follow-ups with your healthcare provider will help monitor your progress and adjust the dosage if necessary.

Evorel Conti is used primarily as Hormone Replacement Therapy (HRT) for the treatment of symptoms of menopause in women. It is a type of medication that combines two hormones, estradiol (a type of estrogen) and norethisterone (a type of progestogen), to help balance hormone levels and alleviate menopausal symptoms.

This medication comes in the form of a patch that is applied directly to the skin. It is typically recommended to apply the patch to a clean, dry, and hairless area of the skin below the waist. The patches should not be applied to the breasts or areas where they may be rubbed off by tight clothing. A new patch should be applied twice a week, preferably on the same days each week, and the old patch should be removed before applying a new one.

It is important to note that Evorel Conti should be used exactly as prescribed by a healthcare professional. The dosage and duration of therapy will depend on the individual's symptoms and overall health condition. It is not recommended to use more than the prescribed dose or for a longer period of time than advised. If symptoms persist or worsen, or if any unusual side effects occur, it is advised to seek medical attention immediately.

When using Evorel Conti, it is important to take certain precautions to ensure its safe and effective use. These precautions are intended to help you avoid negative interactions and side effects, and to maximize the benefits of the medication.

Firstly, before starting treatment with Evorel Conti, inform your doctor if you have any pre-existing conditions such as liver disease, kidney disease, heart disease or if you have a history of blood clots or stroke. The presence of these conditions may affect how you should use this medication.

Secondly, it is important to inform your doctor or pharmacist of all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal products. Evorel Conti may interact with other medications, which can alter how your medications work or increase your risk for serious side effects.

Thirdly, if you are pregnant, planning to become pregnant, or are breastfeeding, consult your doctor before starting Evorel Conti. This medication can have negative effects on an unborn or breastfeeding child.

Lastly, avoid smoking and limit your alcohol intake while using Evorel Conti. Smoking increases your risk of blood clots, stroke, and heart disease, while alcohol can increase the risk of side effects.

Interactions refer to the way in which different drugs react when they are taken at the same time. The interactions between Evorel Conti and other medications can result in different effects than when taken separately. This can lead to decreased effectiveness or an increase in side effects.

Evorel Conti can interact with several drugs. These include:

• Barbiturates, carbamazepine, phenytoin, or primidone (These drugs can reduce the effectiveness of Evorel Conti)
• Anticoagulant drugs (The effect of these drugs can be altered when taken with Evorel Conti)
• Medications for hypertension (The effect of these drugs can be enhanced when taken with Evorel Conti)
• Antidiabetic medication (The effect of these drugs can be decreased when taken with Evorel Conti)

It is important to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs, vitamins, and herbal supplements, to prevent any unwanted interactions with Evorel Conti. Never start or stop taking any medication without consulting your healthcare provider.

The cost of medication can be a significant consideration for many patients, and it is essential to know the price of Evorel Conti when planning your treatment. The price of Evorel Conti can vary depending on several factors, such as the strength of the patches, the number of patches in a pack, and the country where you are purchasing them.

The price can also fluctuate depending on whether you have insurance coverage or if you are paying out-of-pocket. Some online pharmacies may offer lower prices, but it's crucial to ensure they are reputable and authorized to sell this medication.

In the UK, the price of Evorel Conti is approximately £15.99 for a pack of 8 patches, but this can vary. In the US, the price is typically higher due to differences in healthcare systems and can range from $50 to $100 for the same pack size. It's recommended to check current prices with your local pharmacy or online.

Remember, the price of the medication should not be the only factor when choosing your treatment. The effectiveness, side effects, and your personal medical history should also be considered. Always consult with a healthcare professional before making any decisions about your treatment.

When it comes to hormone replacement therapy, there are a variety of options available, of which Evorel Conti is one. However, not all patients can tolerate or benefit from Evorel Conti. In such scenarios, medical professionals may suggest substitutes for Evorel Conti. These substitutes have a similar composition and effect, but may differ in some aspects like dosage and side-effects.

Some of the common substitutes for Evorel Conti include:

• Estalis Continuous Patches: These contain the same active ingredients, estradiol and norethisterone, and are used as a form of continuous combined HRT for postmenopausal women.
• FemSeven Conti patches: Containing estradiol and levonorgestrel, these patches are effective in treating menopausal symptoms and preventing osteoporosis.
• Kliovance tablets: These tablets contain estradiol and norethisterone and are used to treat menopausal symptoms and osteoporosis in postmenopausal women.

It's important to note that these substitutes should not be used without the guidance of a healthcare professional. Each substitute has its own set of benefits, risks, and contraindications. Therefore, the decision to switch from Evorel Conti to a substitute should be made in consultation with a doctor.