Desogestrel - side effects, dosage, indications, contraindications

Desogestrel, a synthetic progestogen, works by primarily inhibiting the process of ovulation. It does this by suppressing the secretion of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby preventing the maturation and subsequent release of the ovarian follicle. Activating the progesterone receptors in the pituitary gland and ovaries, it tricks the body into thinking it's already pregnant, hence stopping further ovulation.

In addition to this primary mode of action, Desogestrel also creates changes in the cervical mucus and the endometrium. The thickening of the cervical mucus prevents sperm from entering the uterus while the alteration in the endometrium prevents successful implantation of any fertilized egg.

Moreover, desogestrel also has a weak anti-estrogenic effect, meaning it can block the effects of estrogen in the body. This combination of actions provides highly effective contraceptive protection.

Desogestrel is primarily indicated for use as a contraceptive. It is a progestin hormone that prevents ovulation, the release of an egg from the ovaries. It also changes the cervical mucus and uterine lining, making it harder for sperm to reach the uterus and for a fertilized egg to attach to the uterus.

Desogestrel is used for:

• Preventing pregnancy
• Treating certain menstrual problems or to regulate periods
• Decreasing blood loss and painful periods
• Decreasing the risk of ovarian cysts

It is important to note that Desogestrel does not protect against sexually transmitted infections (STIs), so you should use it in combination with barrier contraceptives for STI protection.

Desogestrel, like any other medication, has specific contraindications. It is essential for individuals considering this drug to familiarize themselves with these contraindications to avoid harmful effects or complications.

Firstly, Desogestrel should not be used by people who are allergic to its components. An allergic reaction may manifest as rash, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat.

Moreover, Desogestrel is contraindicated in women who are pregnant or suspect they may be pregnant. The drug may harm an unborn baby or cause pregnancy complications. Women should also avoid this drug if they have uncontrolled high blood pressure, uncontrolled diabetes, or a history of heart disease or stroke.

Desogestrel is also contraindicated in conditions like liver disease or tumors, current or past breast cancer, unusual vaginal bleeding, and certain types of severe migraine headaches.

Furthermore, individuals with a history of blood clotting disorders, deep vein thrombosis, or pulmonary embolism should avoid Desogestrel.

Lastly, women who smoke and are over 35, or those with a history of jaundice caused by pregnancy or birth control pills, should not use Desogestrel.

It is crucial to discuss your medical history with your healthcare provider before starting Desogestrel. This helps to ensure that the medication is safe for you. Always follow your doctor's advice regarding the use of this drug.

When taking Desogestrel, it is important to be aware of its potential side effects. While many individuals taking Desogestrel will experience little or no side effects, some may experience unwanted effects. Monitoring for side effects and reporting any changes to your prescribing healthcare provider is vital.

Common side effects of Desogestrel include headaches, breast pain or tenderness, nausea, and changes in menstrual periods such as irregular bleeding or spotting. These effects are generally mild and often resolve over time.

• Headaches: If these become severe or persist, consult your doctor or pharmacist.
• Breast pain or tenderness: This is usually temporary and occurs in response to hormonal changes.
• Nausea: Taking the pill with food may help minimize this effect.
• Changes in menstrual periods: Irregular bleeding or spotting can happen, particularly during the first few months of use.

Severe side effects are less common but require immediate medical attention. These include severe abdominal pain, chest pain, eye problems such as sudden changes in vision or difficulty wearing contact lenses, severe headaches, or leg pain or swelling.

Desogestrel may also cause changes in weight, mood changes, and decreased sex drive. If any of these side effects persist or worsen, it is essential to seek medical assistance immediately.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The dosage of Desogestrel varies depending on the specific needs of the patient and the condition to be treated. It is crucial to follow the physician's prescription instructions strictly to obtain the best results and avoid potential side effects.

Generally, the starting dosage for desogestrel is one tablet (75 micrograms) taken orally once daily. The tablet should be taken at the same time each day to ensure consistent levels of the medication in your bloodstream. It is essential to begin taking Desogestrel on the first day of your menstrual cycle, also known as 'Day 1 start'.

If it is not possible to start on the first day of your menstrual cycle, a 'Quick Start' method can be employed where the first tablet is taken immediately, regardless of the menstrual cycle day, but additional contraceptive measures (like condoms) should be used for the next seven days.

In case a dose is missed, it should be taken as soon as remembered. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take two doses at the same time or extra doses as it can lead to overdose.

Always consult your healthcare professional if you are unsure about any aspect of your medication or if you have specific questions related to Desogestrel dosage.

Desogestrel, an oral contraceptive pill, is primarily used to prevent unwanted pregnancies. It can be used by women of all ages who are sexually active and want to avoid the risk of becoming pregnant.

Desogestrel works by stopping ovulation and thickening the mucus in the cervix, which makes it harder for sperm to reach the egg. It also thins the lining of the uterus, making it less likely that a fertilized egg will implant and grow.

To use Desogestrel, it should be taken at the same time every day, without a break between packs. If a pill is missed, it should be taken as soon as it is remembered, even if it means taking two pills at once.

Desogestrel should not be used by women who are already pregnant or breastfeeding. Additionally, it may not be suitable for women with certain medical conditions, such as a history of blood clots, heart disease, or certain types of cancer. It is important to discuss these risks with a healthcare provider before starting Desogestrel.

While taking Desogestrel, women should continue to have regular check-ups to monitor their health and ensure the medication is working effectively. They should also be aware of the signs and symptoms of potential side effects, such as unexpected bleeding, mood changes, or weight gain.

In summary, Desogestrel is a highly effective method of contraception when used properly. However, like all medications, it must be used responsibly and under the supervision of a healthcare provider.

When it comes to the precautions related to the use of Desogestrel, they are quite significant and must be adhered to ensure safe and effective use. Failure to follow these precautions can lead to serious health implications, hence, they should be seriously considered by all users.

First and foremost, Desogestrel should not be used by women who are breastfeeding. It may pass into breast milk and could have undesirable effects on a nursing infant. Therefore, it is advisable to consult a healthcare provider before taking this medicine if you are nursing a baby.

Desogestrel may increase the risk of blood clots, especially in individuals with a history of such conditions or who are over the age of 35 and smoke. Consequently, if you have a history of blood clots or stroke, or if you smoke and are over 35, you should discuss this with your healthcare provider before starting Desogestrel.

It is crucial to inform your healthcare provider about any allergies you might have before starting on Desogestrel. This is because this product may contain inactive ingredients which can cause allergic reactions or other issues.

Before using Desogestrel, make sure to tell your doctor about your medical history, particularly if it includes high blood pressure, diabetes, high cholesterol or fats, depression, severe headaches, gallbladder disease, liver disease, cancer, among others.

Lastly, Desogestrel may cause dark patches on your skin, especially on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths.

These are the main precautions you should take when using Desogestrel. However, this is not a complete list, and other precautions may apply. It is always advisable to consult a healthcare provider for a comprehensive list of precautions and for personalized advice.

Interactions of Desogestrel with other drugs can affect the way it works or increase the risk of serious side effects. It is important to keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. They can help you manage drug interactions. Here are some noteworthy interactions:

• Other hormonal contraceptives: Using two hormonal contraceptives together can increase the risk of side effects.
• Medications affecting liver enzymes: Drugs like rifampin, bosentan, felbamate, griseofulvin, and certain protease inhibitors may decrease the effectiveness of Desogestrel.
• Antibiotics: Some antibiotics like rifamycin, penicillin, and tetracycline may reduce the effectiveness of Desogestrel.
• Anticonvulsants: Medications used to prevent seizures, such as phenytoin, carbamazepine, and phenobarbital, can also decrease the effectiveness of Desogestrel.

It's important to note that this is not a complete list of possible drug interactions. Always consult with your healthcare provider about the medications you are currently taking and any potential interactions with Desogestrel.

The price of Desogestrel can vary significantly depending on several factors. These include the brand, the dosage, and the location where it is being purchased. It's also important to note that the cost can be influenced by whether or not a health insurance plan covers the medication.

In the United States, for example, the average cash price of Desogestrel can range from $20 to $50 for a supply of 28 tablets, depending on the pharmacy you visit. In some cases, you might be able to find lower prices through prescription savings programs or by shopping at different pharmacies.

Online pharmacies can also offer competitive prices, but it's crucial to ensure that you're purchasing from a reputable source. Counterfeit medications are a widespread problem, and purchasing from an unverified online pharmacy could put your health at risk.

It's also worth mentioning that the price of Desogestrel is subject to change. Factors like manufacturer pricing policies, market demand, and even changes in health insurance coverage can all influence the cost. Therefore, it's a good idea to check the price regularly if you're taking this medication long-term.

When it comes to choosing a substitute for Desogestrel, it is essential to consult with a healthcare provider or a pharmacist. Substitutes should have the same active ingredients, strength, and dosage form and must be approved by a recognized health authority.

Below are some of the substitutes that are commonly prescribed in place of Desogestrel:

• Ethinylestradiol

• Norethindrone

• Levonorgestrel

• Norgestimate

• Etonogestrel

Keep in mind that these substitutes may have different side effects, interactions, and precautions. Therefore, they should only be taken under the supervision of a qualified healthcare provider.

Also, note that the cost, availability, and insurance coverage for each substitute can vary. It's important to discuss these factors with your healthcare provider or pharmacist to ensure that the substitute is suitable for your specific circumstances.